反应详情

温度

80 °C

A mixture of 1.46 g of N-[(2,2-dimethoxy)ethyl]-N-(2-pyridyl)cyclohexanecarboxamide, 0.05 g of 1,4-hydroquinone, and 25 ml of 2N HCl was stirred at 80° C. for 20 min under nitrogen stream. Afterwards, it was cooled at 0° C., diluted with 50 ml of methylene chloride, and alkalinized to pH=10 with 20% aqueous Na2CO3. The aqueous layer was extracted twice with methylene chloride and the combined organic layers were dried (sodium sulfate) and evaporated to dryness in vacuo affording 0.94 g of the title compound, used without further purification in the next reaction step.

1. temperatureAfterwards, it was cooled at 0° C.
2. extractionThe aqueous layer was extracted twice with methylene chloride
3. dry with materialthe combined organic layers were dried (sodium sulfate)
4. customevaporated to dryness in vacuo