Hydrochloric Acid → HCID 70255721, compound

HRID 1603709Notes

Reaction equation

HRID 1603709 reaction equation
[O:1]=[C:2]1[NH:7][C:6]2[C:8]3[CH:9]=[CH:10][CH:11]=[C:12]([CH2:15][C:16]([O:18]CC)=[O:17])[C:13]=3[CH2:14][C:5]=2[N:4]2[CH:21]=[C:22]([CH2:24][C:25]([O:27]CC)=[O:26])[N:23]=[C:3]12.[ClH:30]>O>[ClH:30].[O:1]=[C:2]1[NH:7][C:6]2[C:8]3[CH:9]=[CH:10][CH:11]=[C:12]([CH2:15][C:16]([OH:18])=[O:17])[C:13]=3[CH2:14][C:5]=2[N:4]2[CH:21]=[C:22]([CH2:24][C:25]([OH:27])=[O:26])[N:23]=[C:3]12

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18694017HCID 18694017, compound

Product 1

HCID 70255721HCID 70255721, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 0.68 g of diethyl 4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-2,9-diacetate and 20 ml of 6 N hydrochloric acid is heated for 16 hours at a temperature close to 100° C. The reaction mixture is cooled on a water and ice bath and the suspension is filtered. The insoluble matter is washed with 3×10 ml of acetone and dried under vacuum (1 mm Hg; 0.13 kPa) at close to 60° C. 0.43 g of 4,5dihydro-4-oxo-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-2,9-diacetic acid hydrochloride is obtained in the form of a dark beige solid melting above 250° C. [Analysis: C17H13N3O5, HCl, % calculated C: 54.34, H: 3.76, Cl: 9.43, N: 11.18, O: 21.29, % found C: 53.9, H: 3.4, Cl: 9.8, N: 10.9, O: 20.9].

Workup

  1. temperatureis heated for 16 hours at a temperature
  2. customclose to 100° C
  3. filtrationthe suspension is filtered
  4. washThe insoluble matter is washed with 3×10 ml of acetone
  5. customdried under vacuum (1 mm Hg; 0.13 kPa)
  6. customat close to 60° C

Sources & evidence

ORD record
ord-2608f574c1a3472db4c4a04002f19328
Source dataset
uspto-grants-1999_11
Patent number
US05990108

Reaction notes

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