Dimethylformamide → HCID 16792745, compound

HRID 1603769Notes

Reaction equation

HRID 1603769 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][S:8]([C:11]2[CH:12]=[C:13]([N+:17]([O-])=O)[CH:14]=[CH:15][CH:16]=2)(=[O:10])=[O:9])[CH:2]=1.CN(C)C=O>C(O)C.[Pd]>[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([NH:7][S:8]([C:11]2[CH:12]=[C:13]([NH2:17])[CH:14]=[CH:15][CH:16]=2)(=[O:10])=[O:9])[CH:2]=1

Participants

5

Reactant 2

HCID 6228DimethylformamideHCID 2885772HCID 2885772, compound

Product 1

HCID 16792745HCID 16792745, compoundYield 98.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

To a solution of 3-(pyrid-3-ylaminosulphonyl)-nitrobenzene (4.279 g, 15.3 mmol) in ethanol (500 ml)/dimethylformamide (50 ml) was added 10% palladium catalyst on charcoal (1 g) and the reaction mixture was hydrogenated at atmospheric pressure for 2 hours. The reaction mixture was then filtered through kieselguhr before being evaporated under reduced pressure to give the product as a white solid (3.749 g, 98%)

Workup

  1. filtrationThe reaction mixture was then filtered through kieselguhr
  2. custombefore being evaporated under reduced pressure

Sources & evidence

ORD record
ord-a4a54b32c3c4405d919269d4f6b32552
Source dataset
uspto-grants-1999_11
Patent number
US05990133

Reaction notes

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