Hydrogen Bromide → HCID 70247924, compound

HRID 1603851Notes

Reaction equation

HRID 1603851 reaction equation
Cl.C[O:3][C:4]1[C:18]([C:19]([OH:21])=[O:20])=[CH:17][C:7]2[N:8]([C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[CH:9]=[N:10][C:6]=2[CH:5]=1.[BrH:22]>C(O)(=O)C>[BrH:22].[OH:3][C:4]1[C:18]([C:19]([OH:21])=[O:20])=[CH:17][C:7]2[N:8]([C:11]3[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=3)[CH:9]=[N:10][C:6]=2[CH:5]=1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 70247567HCID 70247567, compound

Product 1

HCID 70247924HCID 70247924, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 5-methoxy-1-phenylbenzimidazole-6-carboxylic acid hydrochloride (0.60 g, 2.24 mmol) in a 33% solution of HBr in glacial acetic acid (50 mL) was refluxed for 30 hours. After cooling to room temperature, the resulting precipitate of the hydrobromide salt of Example 52 was filtered off (0.51 g, 68%): mp 288-290° C. (dec.).

Workup

  1. filtrationthe resulting precipitate of the hydrobromide salt of Example 52 was filtered off (0.51 g, 68%)

Sources & evidence

ORD record
ord-e67b45e369694603ac78acaff264847c
Source dataset
uspto-grants-1999_11
Patent number
US05990146

Reaction notes

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