2-(Benzyloxymethyl)-6-chromanecarboxylic acid → Methanol

HRID 1603885Notes

Reaction equation

HRID 1603885 reaction equation
[CH2:1]([O:8][CH2:9][CH:10]1[CH2:19][CH2:18][C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:20]([OH:22])=O)[CH:16]=2)[O:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:23][C:24]1[C:33]2[O:32][C:31]([C:34]3[NH:38][N:37]=[N:36][N:35]=3)=[CH:30][C:29](=[O:39])[C:28]=2[CH:27]=[CH:26][CH:25]=1>>[O:39]=[C:29]1[C:28]2[CH:27]=[CH:26][CH:25]=[C:24]([NH:23][C:20]([C:15]3[CH:16]=[C:17]4[C:12](=[CH:13][CH:14]=3)[O:11][CH:10]([CH2:9][O:8][CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:19][CH2:18]4)=[O:22])[C:33]=2[O:32][C:31]([C:34]2[NH:38][N:37]=[N:36][N:35]=2)=[CH:30]1.[CH3:1][OH:8]

Participants

4

Reactant 2

HCID 196062512-(Benzyloxymethyl)-6-chromanecarboxylic acidHCID 178507421HCID 178507421, compound

Product 2

HCID 887MethanolYield 57%HCID 178521894HCID 178521894, compound

Procedure

Following the process described in example 1 (point K), starting from 2-(benzyloxymethyl)-6-chromanecarboxylic acid and 8-amino-4-oxo-2-(5-1H-tetrazolyl)-4H-1-benzopyran, the title compound was prepared as a white solid with melting point 214-216° C., which was purified by crystallization in methanol (57% yield).

Sources & evidence

ORD record
ord-f6e22a73f39341e7a2428afa46aa3f31
Source dataset
uspto-grants-1999_11
Patent number
US05990142

Reaction notes

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