HRID1603899

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7268

Diethyl oxalate

C6H10O4

结构：CC(=O)c1cccc(NC(=O)c2ccc3c(c2)CC(COCc2ccccc2)O3)c1O

HCID19606298

未命名化合物

PRODUCTS

生成物

HCID702

Ethanol

C2H6O

收率 73%

结构：CCOC(=O)c1cc(=O)c2cccc(NC(=O)c3ccc4c(c3)CC(COCc3ccccc3)O4)c2o1

HCID19606283

未命名化合物

PROCEDURE

实验过程

Following the process described in example 1 (point A), starting from N-(3-acetyl-2-hydroxyphenyl)-2-benzyloxymethyl-2,3-dihydrobenzofuran-5-carboxamide and diethyl oxalate, the title compound was prepared as a yellow solid with melting point 166-168° C. and purified by crystallization in ethanol (73% yield).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5bc5d74c8eb244a3bc4e519c19b210c1
来源数据集: uspto-grants-1999_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05990142
来源说明: uspto-grants-1999_11

反应 SMILES

[C:1]([C:4]1[C:5]([OH:31])=[C:6]([NH:10][C:11]([C:13]2[CH:14]=[CH:15][C:16]3[O:20][CH:19]([CH2:21][O:22][CH2:23][C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)[CH2:18][C:17]=3[CH:30]=2)=[O:12])[CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].[C:32](OCC)(=O)[C:33]([O:35][CH2:36][CH3:37])=[O:34]>>[CH2:23]([O:22][CH2:21][CH:19]1[CH2:18][C:17]2[CH:30]=[C:13]([C:11]([NH:10][C:6]3[C:5]4[O:31][C:32]([C:33]([O:35][CH2:36][CH3:37])=[O:34])=[CH:2][C:1](=[O:3])[C:4]=4[CH:9]=[CH:8][CH:7]=3)=[O:12])[CH:14]=[CH:15][C:16]=2[O:20]1)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1.[CH2:1]([OH:3])[CH3:2]