Phenethyl bromide → HCID 19606320, compound

HRID 1603906Notes

Reaction equation

HRID 1603906 reaction equation
[Cl:1][C:2]1[C:10]2[O:9][CH:8]([CH2:11]OS(C(F)(F)F)(=O)=O)[CH2:7][C:6]=2[CH:5]=[C:4]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH:3]=1.Br[CH2:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1>>[Cl:1][C:2]1[C:10]2[O:9][CH:8]([CH2:11][CH2:26][CH2:27][C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:7][C:6]=2[CH:5]=[C:4]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH:3]=1

Participants

3

Reactant 2

HCID 7666Phenethyl bromideHCID 19606269HCID 19606269, compound

Product 1

HCID 19606320HCID 19606320, compoundYield 58%

Procedure

Following the process described in example 3 (point B), starting from ethyl 7-chloro-2-trifluoromethanesulfonyloxymethyl-2,3-dihydrobenzofuran-5-carboxylate and 2-bromoethylbenzene, the title compound was prepared, which was purified by chromatography through a silica gel column, eluting with petroleum ether:ethyl acetate, 95:5 (58% yield).

Workup

  1. customwhich was purified by chromatography through a silica gel column
  2. washeluting with petroleum ether

Sources & evidence

ORD record
ord-4d3b7e67f8e343268f04d0584a4771d5
Source dataset
uspto-grants-1999_11
Patent number
US05990142

Reaction notes

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