3-Amino-2-hydroxyacetophenone → HCID 19606273, compound

HRID 1603913Notes

Reaction equation

HRID 1603913 reaction equation
[Cl:1][C:2]1[C:19]([C:20]([OH:22])=O)=[CH:18][C:5]2[CH2:6][CH:7]([CH2:9][CH2:10][CH2:11][C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[O:8][C:4]=2[CH:3]=1.[CH3:23][C:24]([C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([NH2:32])[C:27]=1[OH:33])=[O:25]>>[C:24]([C:26]1[C:27]([OH:33])=[C:28]([NH:32][C:20]([C:19]2[C:2]([Cl:1])=[CH:3][C:4]3[O:8][CH:7]([CH2:9][CH2:10][CH2:11][C:12]4[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=4)[CH2:6][C:5]=3[CH:18]=2)=[O:22])[CH:29]=[CH:30][CH:31]=1)(=[O:25])[CH3:23]

Participants

3

Reactant 2

HCID 4592943-Amino-2-hydroxyacetophenoneHCID 19606252HCID 19606252, compound

Product 1

HCID 19606273HCID 19606273, compoundYield 42%

Procedure

Following the process described in example 1 (point K), starting from 6-chloro-2-(3-phenylpropyl)-2,3-dihydrobenzofuran-5-carboxylic acid and 3-amino-2-hydroxyacetophenone, the title compound was prepared, which was purified by chromatography through a silica gel column, eluting with hexane:ethyl acetate, 1:1 (42% yield).

Workup

  1. customwhich was purified by chromatography through a silica gel column
  2. washeluting with hexane

Sources & evidence

ORD record
ord-0cda1be28ce74763ad8a1be4ededc2ae
Source dataset
uspto-grants-1999_11
Patent number
US05990142

Reaction notes

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