反应详情

A suspension of lithium aluminium hydride (309 mg, 7.62 mmol) in anhydrous tetrahydrofuran (65 ml) was added under inert atmosphere with a solution of 4-(4-phenylbutoxy)benzoic acid (1.03 g, 3.81 mmol) in 20 ml of dry ethyl ether. The mixture was left under stirring at room temperature for 2 hours, after that was added slowly with a NaCl saturated solution in water (80 ml), the two phases were separated and the aqueous one was extracted with ethyl acetate (3×50 ml). The organic extracts were dried and the solvent was evaporated off to obtain a crude, which was digested with ethyl ether. The digestion extracts were evaporated under reduced pressure to obtain 556 mg of the title compound (57% yield).

1. waitThe mixture was left
2. customthe two phases were separated
3. extractionthe aqueous one was extracted with ethyl acetate (3×50 ml)
4. customThe organic extracts were dried
5. customthe solvent was evaporated off
6. customto obtain a crude, which
7. customThe digestion extracts were evaporated under reduced pressure