Benzenebutanol → HCID 19606259, compound

HRID 1603936Notes

Reaction equation

HRID 1603936 reaction equation
[F:1][C:2]1[CH:11]=[C:10]([OH:12])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[C:13]1([CH2:19][CH2:20][CH2:21][CH2:22]O)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:13]1([CH2:19][CH2:20][CH2:21][CH2:22][O:12][C:10]2[CH:9]=[CH:8][C:3]([C:4]([O:6][CH3:7])=[O:5])=[C:2]([F:1])[CH:11]=2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

3

Reactant 2

HCID 76889BenzenebutanolHCID 22463192Methyl 2-fluoro-4-hydroxybenzoate

Product 1

HCID 19606259HCID 19606259, compoundYield 97%

Procedure

Following the process described in example 18 (point A), starting from methyl 2-fluoro-4-hydroxybenzoate and 4-phenyl-1-butanol, the title compound was prepared, which was purified by chromatography through a silica gel column, eluting with hexane:ethyl acetate, 95:5 (97% yield).

Workup

  1. customwhich was purified by chromatography through a silica gel column
  2. washeluting with hexane

Sources & evidence

ORD record
ord-62a8419acf474dba82c5a170cf42a853
Source dataset
uspto-grants-1999_11
Patent number
US05990142

Reaction notes

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