Diethyl Ether → HCID 19606247, compound

HRID 1603940Notes

Reaction equation

HRID 1603940 reaction equation
[F:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][O:7][CH2:8][C:9]2(C(OCC)=O)[CH2:13][C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[O:10]2)=[CH:4][CH:3]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3].[CH2:31]([O:33]CC)C>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][O:7][CH2:8][CH:9]2[CH2:13][C:12]3[CH:14]=[C:15]([CH2:31][OH:33])[CH:16]=[CH:17][C:11]=3[O:10]2)=[CH:23][CH:24]=1

Participants

4

Reactant 3

HCID 3283Diethyl EtherHCID 21226445Aluminium lithium hydrideHCID 70149208HCID 70149208, compound

Product 1

HCID 19606247HCID 19606247, compoundYield 83%

Procedure

Following the process described in example 18 (point C), starting from ethyl 2-(4'-fluorobenzyloxymethyl)-2,3-dihydrobenzofuran-2-carboxylate (7.00 g, 23.2 mmol), LiAlH4 (3.51 g, 92.6 mmol) and dry ethyl ether (300 ml), the title compound was prepared (83% yield).

Sources & evidence

ORD record
ord-8d2c533ae4ee40c7ae9325c07e0f43e6
Source dataset
uspto-grants-1999_11
Patent number
US05990142

Reaction notes

Loading…