Hydrochloric Acid → HCID 18429239, compound

HRID 1604147Notes

Reaction equation

HRID 1604147 reaction equation
C([O:4][CH2:5][C:6]([N:8]([CH2:31][CH2:32][O:33]C(=O)C)[C:9]1[C:10]([I:30])=[C:11]([C:17]([I:29])=[C:18]([NH:21][C:22](=[O:28])[CH2:23][O:24]C(=O)C)[C:19]=1[I:20])[CH2:12]CC([O-])=O)=[O:7])(=O)C.Cl.C[OH:39]>O.[OH-].[Na+]>[OH:4][CH2:5][C:6]([N:8]([CH2:31][CH2:32][OH:33])[C:9]1[C:10]([I:30])=[C:11]([C:17]([I:29])=[C:18]([NH:21][C:22](=[O:28])[CH2:23][OH:24])[C:19]=1[I:20])[CH2:12][OH:39])=[O:7]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 18429234HCID 18429234, compound

Product 1

HCID 18429239HCID 18429239, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 14798Sodium HydroxideSolvent

Procedure

N,N'-Bis(acetoxyacetyl)-N-(2-acetoxyethyl)-3,5-diamino-2,4,6-triiodobenzylacetate (0.50 g, 0.59 mmol) was dissolved in a mixture of methanol (5 ml), water (5 ml) and aqueous 1 M NaOH (1 ml). The solution was stirred for 2 h, pH was adjusted to 2 using aqueous HCl and the product was purified by preparative HPLC. Yield: 240 mg (67%).

Workup

  1. customthe product was purified by preparative HPLC

Sources & evidence

ORD record
ord-2ab9b77bb34a44a0afb9fd5d6e35fcd6
Source dataset
uspto-grants-1999_11
Patent number
US05993780

Reaction notes

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