Hydrochloric Acid → HCID 18429145, compound

HRID 1604150Notes

Reaction equation

HRID 1604150 reaction equation
C([O:4][CH:5]([CH3:32])[C:6]([NH:8][C:9]1[C:10]([I:31])=[C:11]([C:17]([I:30])=[C:18]([NH:21][C:22](=[O:29])[CH:23]([O:25]C(=O)C)[CH3:24])[C:19]=1[I:20])[CH2:12]CC([O-])=O)=[O:7])(=O)C.[OH-:33].[Na+].Cl>CO.O>[OH:4][CH:5]([CH3:32])[C:6]([NH:8][C:9]1[C:10]([I:31])=[C:11]([C:17]([I:30])=[C:18]([NH:21][C:22](=[O:29])[CH:23]([OH:25])[CH3:24])[C:19]=1[I:20])[CH2:12][OH:33])=[O:7]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 18429210HCID 18429210, compound

Product 1

HCID 18429145HCID 18429145, compoundYield 46%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

N,N'-Bis(2-acetoxypropionyl)-3,5-diamino-2,4,6-triiodobenzylacetate (0.16 g, 0.2 mmol) was dissolved in a mixture of methanol (5 ml) and water (5 ml) and the pH was adjusted to 12 using a 1 M aqueous solution of NaOH. After stirring for 15 h, the solution was neutralized with 1 M HCl and the solvents were removed by evaporation. Purification by preparative HPLC gave 61 mg (46%) of the pure product.

Workup

  1. customthe solvents were removed by evaporation
  2. customPurification by preparative HPLC

Sources & evidence

ORD record
ord-1eef59fa5e4f49018dee3062b6279906
Source dataset
uspto-grants-1999_11
Patent number
US05993780

Reaction notes

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