Potassium Carbonate → HCID 18429271, compound

HRID 1604178Notes

Reaction equation

HRID 1604178 reaction equation
CC1(C)[O:6][CH:5]([C:7]([NH:9][C:10]2[C:11]([I:37])=[C:12]([CH2:32][O:33]C(=O)C)[C:13]([I:31])=[C:14]([C:29]=2[I:30])[C:15]([NH:17][CH2:18][CH:19]([O:25]C(=O)C)[CH2:20][O:21]C(=O)C)=[O:16])=[O:8])[CH2:4][O:3]1.C(=O)([O-])[O-].[K+].[K+]>CO>[OH:6][CH:5]([CH2:4][OH:3])[C:7]([NH:9][C:10]1[C:11]([I:37])=[C:12]([CH2:32][OH:33])[C:13]([I:31])=[C:14]([C:29]=1[I:30])[C:15]([NH:17][CH2:18][CH:19]([OH:25])[CH2:20][OH:21])=[O:16])=[O:8]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 18429160HCID 18429160, compound

Product 1

HCID 18429271HCID 18429271, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

5-(2,2-Dimethyl-1,3-dioxolane-4-carbamido)-3-acetoxymethyl-N-(2,3-diacetoxypropyl)-2,4,6-triiodobenzamide (0.80 g, 9.16 mmol) was dissolved in methanol (7 ml) and potassium carbonate (0.17 g, 12,3 mmol) was added. The mixture was stirred at room temperature for 17 h. The mixture was filtered and pH of the filtrate was adjusted to 1 using aqueous 5M hydrochloric acid, and the mixture was stirred for further 5 h at room temperature. The reaction mixture was then evaporated to a solid residue, which was purified by preparative HPLC. Yield: 0.41 g (49%) of a white freeze dried product.

Workup

  1. filtrationThe mixture was filtered
  2. stirringthe mixture was stirred for further 5 h at room temperature
  3. customThe reaction mixture was then evaporated to a solid residue, which
  4. customwas purified by preparative HPLC

Sources & evidence

ORD record
ord-652c9b5c3e8944f0a3225b67ae742158
Source dataset
uspto-grants-1999_11
Patent number
US05993780

Reaction notes

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