Sodium Hydroxide → HCID 19602326, compound

Participants

Reaction Steps

A mixture of the product of Example 8 (0.6 g, 2.2 mmol) and 1 g of 80-85% 3-chloroperoxybenzoic acid in 16 mL methylene chloride was refluxed for 2 h, then cooled and diluted with additional methylene chloride. The solution was treated sequentially with sat sodium metabisulfite, 1.25N NaOH, and brine; then dried and concentrated in vacuo. Flash chromatography of the residue with 35% ethyl acetate-hexane gave 0.5 g of the desired product as a white solid, a yield of 74.5%. m.p. 135-148° C.

Provenance & Evidence