Diethyl Ether → HCID 19602609, compound

HRID 1604362Notes

Reaction equation

HRID 1604362 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:23][CH:24]2[CH2:28][CH2:27][CH2:26][CH2:25]2)=[C:6]([CH:22]=1)[CH2:7][N:8]([C:11]1[N:16]=[N:15][C:14]([C:17]2NN=NN=2)=[CH:13][CH:12]=1)[CH2:9][CH3:10].[OH-:29].[Na+].CC[O:33]CC>O.C(O)C>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:23][CH2:24][CH:25]2[CH2:28][CH2:27][CH2:26]2)=[C:6]([CH:22]=1)[CH2:7][N:8]([C:11]1[N:16]=[N:15][C:14]([C:17]([OH:33])=[O:29])=[CH:13][CH:12]=1)[CH2:9][CH3:10]

Participants

6

Reactant 3

HCID 3283Diethyl EtherHCID 14798Sodium HydroxideHCID 178463707HCID 178463707, compound

Product 1

HCID 19602609HCID 19602609, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 962WaterSolvent

Procedure

The title compound was prepared from using a similar method to that of example 18 by treating 6-[N-(5-Chloro-2-cyclobutylmethoxybenzyl)-N-ethylamino]-3-cyanopyridazine (reference example 27) (2.3 g, 6.46 mmol) with sodium hydroxide (2.6 g, 65 mmol) in water (20 ml) and ethanol (100 ml) to give a gum which solidified on trituration with ether (1.15 g, 47%).

Workup

  1. customto give a gum which

Sources & evidence

ORD record
ord-97cdd8d79eaa4fbbb0f415fbe124f6af
Source dataset
uspto-grants-1999_11
Patent number
US05994353

Reaction notes

Loading…