Sodium Hydroxide → HCID 15434168, compound

HRID 1604437Notes

Reaction equation

HRID 1604437 reaction equation
[CH:1](/[C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([CH:16]([CH3:21])[C:17]([O:19]C)=[O:18])=[CH:12][CH:11]=2)[CH:7]=[N:8][CH:9]=1)=[CH:2]\[CH3:3].[OH-].[Na+]>CO>[CH:1](/[C:4]1[CH:5]=[C:6]([C:10]2[CH:15]=[CH:14][C:13]([CH:16]([CH3:21])[C:17]([OH:19])=[O:18])=[CH:12][CH:11]=2)[CH:7]=[N:8][CH:9]=1)=[CH:2]\[CH3:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 19603849HCID 19603849, compound

Product 1

HCID 15434168HCID 15434168, compoundYield 89.2%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 14c (38 mg, 0.13 mmol) in methanol (3 mL) was added 2N NaOH (0.1 mL, 0.2 mmol). The light yellow solution was stirred overnight, then concentrated. The residue was partitioned between pH 7 phosphate buffer and EtOAc. The organic phase was washed with brine, dried over MgSO4 and evaporated to provide 31 mg of the title compound as an oil.

Workup

  1. concentrationconcentrated
  2. customThe residue was partitioned between pH 7 phosphate buffer and EtOAc
  3. washThe organic phase was washed with brine
  4. dry with materialdried over MgSO4
  5. customevaporated

Sources & evidence

ORD record
ord-3b64fb0f3e2a45e4b15e8ad822d121ef
Source dataset
uspto-grants-1999_11
Patent number
US05994379

Reaction notes

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