Hydrochloric Acid → HCID 67559246, compound

Participants

Reaction Steps

trans-7-Methoxy-3-phenyl-4-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}chromane (2 g) was dissolved in melted pyridinium chloride, prepared from a mixture of pyridine (10 ml) and conc. hydrochloric acid where the water has been removed by distillation at 140° C. The mixture was heated for 75 min. Cooled down to room temperature. Water was added (15 ml) and pH adjusted to 12 with sodium hydroxide (32.5%). The mixture was extracted with toluene (15 ml). The organic phase was separated, dried over potassium carbonate and evaporated.

Provenance & Evidence