Hydrochloric Acid → HCID 67559246, compound

HRID 1604460Notes

Reaction equation

HRID 1604460 reaction equation
C[O:2][C:3]1[CH:12]=[C:11]2[C:6]([C@@H:7]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][N:28]4[CH2:32][CH2:31][CH2:30][CH2:29]4)=[CH:21][CH:20]=3)[C@H:8]([C:13]3[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=3)[CH2:9][O:10]2)=[CH:5][CH:4]=1.N1C=CC=CC=1.Cl.O>[Cl-].[NH+]1C=CC=CC=1>[OH:2][C:3]1[CH:12]=[C:11]2[C:6]([C@@H:7]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][N:28]4[CH2:32][CH2:31][CH2:30][CH2:29]4)=[CH:21][CH:20]=3)[C@H:8]([C:13]3[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH2:9][O:10]2)=[CH:5][CH:4]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 1049PyridineHCID 21453433382-08-0

Product 1

HCID 67559246HCID 67559246, compound

Reagents, catalysts & solvents 1

HCID 69401Einecs 211-027-4Solvent

Procedure

trans-7-Methoxy-3-phenyl-4-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}chromane (2 g) was dissolved in melted pyridinium chloride, prepared from a mixture of pyridine (10 ml) and conc. hydrochloric acid where the water has been removed by distillation at 140° C. The mixture was heated for 75 min. Cooled down to room temperature. Water was added (15 ml) and pH adjusted to 12 with sodium hydroxide (32.5%). The mixture was extracted with toluene (15 ml). The organic phase was separated, dried over potassium carbonate and evaporated.

Workup

  1. customhas been removed by distillation at 140° C
  2. temperatureThe mixture was heated for 75 min
  3. additionWater was added (15 ml)
  4. extractionThe mixture was extracted with toluene (15 ml)
  5. customThe organic phase was separated
  6. dry with materialdried over potassium carbonate
  7. customevaporated

Sources & evidence

ORD record
ord-3ff5334afd9f42abb4bf1edaea7da8d9
Source dataset
uspto-grants-1999_11
Patent number
US05994390

Reaction notes

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