HCID 19603423, compound → HCID 19603369, compound

HRID 1604542Notes

Reaction equation

HRID 1604542 reaction equation
[CH3:1][C:2]1[C:7]([CH2:8][C:9]([O:11]CC2C=CC=CC=2)=[O:10])=[CH:6][CH:5]=[CH:4][N:3]=1>CO.[Pd].O>[CH3:1][C:2]1[C:7]([CH2:8][C:9]([OH:11])=[O:10])=[CH:6][CH:5]=[CH:4][N:3]=1

Participants

5

Reactant 1

HCID 19603423HCID 19603423, compound

Product 1

HCID 19603369HCID 19603369, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 962WaterSolvent

Procedure

The residue including benzyl 2-(2-methyl-3-pyridyl)acetate obtained in Preparation 29-(2) was dissolved in methanol (5 ml), and 10% palladium on carbon was added thereto. The mixture was stirred under hydrogen atmosphere for 3 hours. The reaction mixture was diluted with water and washed with ethyl acetate. The solvent was removed in vacuo to give 2-(2-methyl-3-pyridyl)acetic acid (90 mg).

Workup

  1. customobtained in Preparation 29-(2)
  2. washwashed with ethyl acetate
  3. customThe solvent was removed in vacuo

Sources & evidence

ORD record
ord-935d536c34d74ca998dcede237776da7
Source dataset
uspto-grants-1999_11
Patent number
US05994368

Reaction notes

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