HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Methyl 6-hydroxymethyl-3-methylquinoline-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl 6-acetoxymethyl-3-methylquinoline-2-carboxylate | HCID 19603481 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 6-hydroxymethyl-3-methylquinoline-2-carboxylate | HCID 19603207 | 5.9% |
Reaction Steps
A mixture of ethyl 6-acetoxymethyl-3-methylquinoline-2-carboxylate (420 mg) and potassium carbonate in methanol was stirred for 30 minutes under ice-cooling. After filtration the filtrate was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with water, dried over magnesium sulfate and concentrated to give methyl 6-hydroxymethyl-3-methylquinoline-2-carboxylate (20 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05994368 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-88db145c2b284e7a8be0441b53a3e69c |
| Source note | uspto-grants-1999_11 |