反应详情

A mixture of ethyl 6-acetoxymethyl-3-methylquinoline-2-carboxylate (420 mg) and potassium carbonate in methanol was stirred for 30 minutes under ice-cooling. After filtration the filtrate was concentrated and partitioned between ethyl acetate and water. The organic layer was washed with water, dried over magnesium sulfate and concentrated to give methyl 6-hydroxymethyl-3-methylquinoline-2-carboxylate (20 mg).

1. temperaturecooling
2. filtrationAfter filtration the filtrate
3. concentrationwas concentrated
4. custompartitioned between ethyl acetate and water
5. washThe organic layer was washed with water
6. dry with materialdried over magnesium sulfate
7. concentrationconcentrated