Acetic Anhydride → HCID 19603381, compound

HRID 1604557Notes

Reaction equation

HRID 1604557 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][C:10]([NH:12][CH2:13][C:14]([N:16]([C:18]2[C:19]([Cl:38])=[C:20]([C:34]([Cl:37])=[CH:35][CH:36]=2)[CH2:21][O:22][C:23]2[CH:24]=[CH:25][CH:26]=[C:27]3[C:32]=2[N:31]=[C:30]([CH3:33])[CH:29]=[CH:28]3)[CH3:17])=[O:15])=[O:11])=[CH:4][CH:3]=1.[C:39](OC(=O)C)(=[O:41])[CH3:40]>ClCCl>[C:39]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([S:8][CH2:9][C:10]([NH:12][CH2:13][C:14]([N:16]([C:18]2[C:19]([Cl:38])=[C:20]([C:34]([Cl:37])=[CH:35][CH:36]=2)[CH2:21][O:22][C:23]2[CH:24]=[CH:25][CH:26]=[C:27]3[C:32]=2[N:31]=[C:30]([CH3:33])[CH:29]=[CH:28]3)[CH3:17])=[O:15])=[O:11])=[CH:4][CH:3]=1)(=[O:41])[CH3:40]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 19603263HCID 19603263, compound

Product 1

HCID 19603381HCID 19603381, compoundYield 49.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of 8-[3-[N-[2-(4-aminophenylthio)-acetylglycyl]-N-methylamino]-2,6-dichlorobenzyloxy]-2-methylquinoline (56 mg) triethylamine (15 mg), and acetic anhydride (15 mg) in dichloromethane (2 ml) was stirred for 4 hours at ambient temperature. The resulting precipitates were collected by filtration to give 8-[3-[N-[2-(4-acetamidophenylthio)acetylglycyl]-N-methylamino)-2,6-dichlorobenzyloxy]-2-methylquinoline (30 mg) as a colorless crystal.

Workup

  1. customThe resulting precipitates
  2. filtrationwere collected by filtration

Sources & evidence

ORD record
ord-7fee253bbe33403c80874a20424da59e
Source dataset
uspto-grants-1999_11
Patent number
US05994368

Reaction notes

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