Hydrochloric Acid → HCID 67566087, compound

Participants

Reaction Steps

To a solution of 8-[N-tert-butoxycarbonyl-N-[2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl)cinnamoylglycyl]amino]benzyl]amino]-2-methylquinoline (32.3 mg) in ethyl acetate (0.5 ml) was added 4N solution of hydrogen chloride in ethyl acetate (0.5 ml) under ice-cooling, and the mixture was stirred for 30 minutes at the same temperature and for 2 hours at ambient temperature. The mixture was concentrated in vacuo to give 8-[2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl)cinnamoylglycyl]amino]benzylamino]-2-methylquinoline dihydrochloride (22.0 mg) as amorphous powder.

Provenance & Evidence