Hydrochloric Acid → HCID 67566087, compound

HRID 1604597Notes

Reaction equation

HRID 1604597 reaction equation
C(OC([N:8]([C:38]1[CH:39]=[CH:40][CH:41]=[C:42]2[C:47]=1[N:46]=[C:45]([CH3:48])[CH:44]=[CH:43]2)[CH2:9][C:10]1[C:15]([Cl:16])=[CH:14][CH:13]=[C:12]([N:17]([CH3:36])[C:18](=[O:35])[CH2:19][NH:20][C:21](=[O:34])[CH:22]=[CH:23][C:24]2[CH:29]=[CH:28][C:27]([C:30](=[O:33])[NH:31][CH3:32])=[CH:26][CH:25]=2)[C:11]=1[Cl:37])=O)(C)(C)C.[ClH:49]>C(OCC)(=O)C>[ClH:16].[ClH:49].[Cl:37][C:11]1[C:12]([N:17]([CH3:36])[C:18](=[O:35])[CH2:19][NH:20][C:21](=[O:34])[CH:22]=[CH:23][C:24]2[CH:25]=[CH:26][C:27]([C:30](=[O:33])[NH:31][CH3:32])=[CH:28][CH:29]=2)=[CH:13][CH:14]=[C:15]([Cl:16])[C:10]=1[CH2:9][NH:8][C:38]1[CH:39]=[CH:40][CH:41]=[C:42]2[C:47]=1[N:46]=[C:45]([CH3:48])[CH:44]=[CH:43]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 53675166HCID 53675166, compound

Product 1

HCID 67566087HCID 67566087, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent2×

Procedure

To a solution of 8-[N-tert-butoxycarbonyl-N-[2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl)cinnamoylglycyl]amino]benzyl]amino]-2-methylquinoline (32.3 mg) in ethyl acetate (0.5 ml) was added 4N solution of hydrogen chloride in ethyl acetate (0.5 ml) under ice-cooling, and the mixture was stirred for 30 minutes at the same temperature and for 2 hours at ambient temperature. The mixture was concentrated in vacuo to give 8-[2,6-dichloro-3-[N-methyl-N-[4-(methylcarbamoyl)cinnamoylglycyl]amino]benzylamino]-2-methylquinoline dihydrochloride (22.0 mg) as amorphous powder.

Workup

  1. temperaturecooling
  2. concentrationThe mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-df5a13b1a1e04f5eb2fb7731b70f9ce9
Source dataset
uspto-grants-1999_11
Patent number
US05994368

Reaction notes

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