Thionyl Chloride → 2-(4-Tert-butylthiazol-2-yl)benzofuran-5-carbonyl chloride hydrochloride

HRID 1604639Notes

Reaction equation

HRID 1604639 reaction equation
[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([C:19]([OH:21])=O)=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:3])[CH3:2].S(Cl)([Cl:24])=O>O1CCCC1>[ClH:24].[C:1]([C:5]1[N:6]=[C:7]([C:10]2[O:11][C:12]3[CH:18]=[CH:17][C:16]([C:19]([Cl:24])=[O:21])=[CH:15][C:13]=3[CH:14]=2)[S:8][CH:9]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 196036942-(4-Tert-butylthiazol-2-yl)benzofuran-5-carboxylic acid

Product 1

HCID 196038312-(4-Tert-butylthiazol-2-yl)benzofuran-5-carbonyl chloride hydrochloride

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 2-(4-tert-butylthiazol-2-yl)benzofuran-5-carboxylic acid (5.0 g) and thionyl chloride (12.1 ml) in tetrahydrofuran (50 ml) was stirred at 50° C. for 2 hours. After the solution was cooled to room temperature, the resulting precipitates were collected by filtration and washed with diisopropyl ether to give 2-(4-tert-butylthiazol-2-yl)benzofuran-5-carbonyl chloride hydrochloride (5.57 g).

Workup

  1. customthe resulting precipitates
  2. filtrationwere collected by filtration
  3. washwashed with diisopropyl ether

Sources & evidence

ORD record
ord-648fb067932a4e0b92fd92299ea25dda
Source dataset
uspto-grants-1999_11
Patent number
US05994378

Reaction notes

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