HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl 1-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]carbonyl}indole-3-carboxylate → 1-{[2-(4-Tert-butylthiazol-2-yl)benzofuran-5-yl]carbonyl}indole-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl 1-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]carbonyl}indole-3-carboxylate | HCID 19603790 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-{[2-(4-Tert-butylthiazol-2-yl)benzofuran-5-yl]carbonyl}indole-3-carboxylic acid | HCID 19603721 | 83.7% |
Reaction Steps
A solution of benzyl 1-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]carbonyl}indole-3-carboxylate (107 mg) in tetrahydrofuran (4 ml) was hydrogenated over 10% Pd--C (22 mg) at room temperature under atmospheric pressure. After removal of the catalyst by filtration, the filtrate was concentrated under reduced pressure to give 1-{[2-(4-tert-butylthiazol-2-yl)benzofuran-5-yl]carbonyl}indole-3-carboxylic acid (74.5 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05994378 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-9e3013588b414ad9992287cf0c9ea83f |
| Source note | uspto-grants-1999_11 |