Benzyl Alcohol → HCID 70117679, compound

HRID 1604738Notes

Reaction equation

HRID 1604738 reaction equation
[ClH:1].[NH2:2][N:3]=[CH:4][NH:5][NH:6][CH2:7][C:8]([OH:10])=[O:9].[CH2:11](O)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[ClH:1].[C:12]1([CH2:11][O:9][C:8](=[O:10])[CH2:7][NH:6][NH:5][CH:4]=[N:3][NH2:2])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

4

Reactant 3

HCID 244Benzyl AlcoholHCID 313Hydrochloric AcidHCID 71349807[2-(Hydrazinylidenemethyl)hydrazinyl]acetic acid

Product 1

HCID 70117679HCID 70117679, compoundYield 82%

Procedure

HCl (g) was bubbled through a suspension of [2-(aminoiminomethyl)hydrazino]-acetic acid (2.00 g, 15.2 mmol) in benzyl alcohol (30 mL). The reaction was stirred for about an hour until everything was in solution. The crude product was precipitated out by adding Et2O. This material was recrystallized from MeOH/EtOAc to yield [2-(aminoiminomethyl)hydrazino] acetic acid phenylmethyl ester monohydrochloride (3.20 g, 82%) as a white crystalline solid. MP: 162-164 ° C. 1H NMR (CD3OD): δ 3.69 (s, 2H), 5.24 (s, 2H), 7.34-7.42 (m, 5H).

Workup

  1. customThe crude product was precipitated out
  2. additionby adding Et2O
  3. customThis material was recrystallized from MeOH/EtOAc

Sources & evidence

ORD record
ord-e4c759672f2e4add8ad364a05f3fc24d
Source dataset
uspto-grants-1999_11
Patent number
US05994577

Reaction notes

Loading…