Water → 2-Bromo-4-chloroanisole

In a 250 mL r.b. flask, a solution of 2-bromo-4-chlorophenol (Lancaster: 16.94 g, 81.6 mmol, 1.0 equivuiv) in acetone (160 mL) was treated sequivuentially with iodomethane (6.10 mL, 98 mmol, 1.2 equivuiv), potassium carbonate (12 g), and water (4 mL). The reaction mixture was heated at reflux for 3 h, cooled to rt, and the bulk of the volatiles was removed under reduced pressure. The residue was poured into water (140 mL) and extracted with EtOAc (3×150 mL). The extracts were washed with brine (1×100 mL, combined, dried (K2CO3), filtered through a pad of Celite™, and concentrated to a clear oil. Short-path distillation (80°-85° C., 1 Torr) afforded 17.74 g (98%) of 2-bromo-4-chloroanisole as a clear liquid. Data for 2-bromo-4-chloroanisole: 1H NMR (400 MHz, acetone-d6) 7.53 (d, J=2.5, 1 H); 7.24 (dd, J=9.7, 2.5, 1 H); 6.81 (d, J=9.7, 1 H); 3.88 (s, 3 H).

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 3 h
3. customthe bulk of the volatiles was removed under reduced pressure
4. additionThe residue was poured into water (140 mL)
5. extractionextracted with EtOAc (3×150 mL)
6. washThe extracts were washed with brine (1×100 mL
7. dry with materialdried (K2CO3)
8. filtrationfiltered through a pad of Celite™
9. concentrationconcentrated to a clear oil
10. distillationShort-path distillation (80°-85° C., 1 Torr)

ORD record

ord-ff9660f12da34b7f8b74d123891f3276

Source dataset

uspto-grants-1999_11

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05994544