HuagongsheHuagongshe Chemistry Print Report · For research reference only
Lithium diisopropylamide → Diisopropylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Lithium diisopropylamide | HCID 2724682 | — |
| Reactant | Trimethyl4-phosphonocrotonate | HCID 71651211 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Diisopropylamine | HCID 7912 | — |
| Product | Butyllithium | HCID 178418339 | — |
Reaction Steps
Alternatively, the solution of trimethyl-4-phosphonocrotonate in THF is deprotonated at -78° C. with a solution of lithium diisopropylamide (LDA), obtained from diisopropylamine and n-butyllithium, in THF, and the obtained anion reacted at -78° C. with a solution of an aldehyde IX in THF.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05994569 |
| Source dataset | uspto-grants-1999_11 |
| ORD ID | ord-5ea4a9ab413a4bdcbc2a3c22dafa88ac |
| Source note | uspto-grants-1999_11 |