HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1604857Generated: October 26, 2026
Acetic Anhydride → N-(4-Chloro-3-hydroxyphenyl)acetamide
https://huagongshe.com/reaction/1604857
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 5-Amino-2-chlorophenol | HCID 80676 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-(4-Chloro-3-hydroxyphenyl)acetamide | HCID 14122483 | — |
Reaction Steps
0.05 Mole (7.17 grams) of 2-chloro-5-aminophenol is dissolved in 21 cc of dioxane at 75°C. There is then added, with agitation, 0.05 mole (5.1 grams) of acetic anhydride. At the end of this addition, the reaction medium is maintained for 10 minutes at 70°C and then cooled. The raw product which has crystallized in then filtered and recrystallized in a hydroalcoholic medium. It exhibits a melting point of 212°C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US03948596 |
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| Source dataset | uspto-grants-1976_04 |
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| ORD ID | ord-e74abaf0848c4bfeba9368c6a280c642 |
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| Source note | uspto-grants-1976_04 |
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