Acrylonitrile → 3-{[2-(3,4-Dimethoxyphenyl)ethyl]amino}propanenitrile
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][NH2:13])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10].[C:14](#[N:17])[CH:15]=[CH2:16]>CO>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:11][CH2:12][NH:13][CH2:16][CH2:15][C:14]#[N:17])[CH:6]=[CH:7][C:8]=1[O:9][CH3:10]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 50 °C
Procedure
54.5 gm of 2-(3,4-dimethoxy-phenyl)-ethylamine were dissolved in 100 ml of methanol, a solution of 16.2 gm of acrylonitrile in 50 ml of methanol was added dropwise at 50°C, and the mixture was stirred for 1 hour at 50°C. After evaporation of the methanol, the raw reaction oriduct thus obtained was used without further purification in the next step.
Workup
- customAfter evaporation of the methanol
- customthe raw reaction oriduct
- customthus obtained
- customwas used without further purification in the next step
Sources & evidence
- ORD record
- ord-e027fe8003ba4079a2b66fa78e02922d
- Source dataset
- uspto-grants-1976_04
- Patent number
- US03948898
Reaction notes
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