Methylamine → HCID 15581954, compound

HRID 1604894Notes

Reaction equation

HRID 1604894 reaction equation
[CH3:1][N:2]([CH3:13])[CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[C:4]([NH2:6])=[S:5].CN.[C:16](=O)([O-])[O-].[Na+].[Na+]>>[CH3:1][N:2]([CH3:13])[CH:3]([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][N:8]=1)[C:4]([NH:6][CH3:16])=[S:5]

Participants

4

Reactant 3

HCID 6329MethylamineHCID 10340Sodium CarbonateHCID 15581953HCID 15581953, compound

Product 1

HCID 15581954HCID 15581954, compound

Procedure

A mixture of 7.5 g. of 2-dimethylamino-2-(2-pyridyl)thioacetamide and 15 ml. of 30% aqueous methylamine is heated for 30 minutes, then cooled and 25 ml. of 5% aqueous sodium carbonate solution is added. The solution is extracted with chloroform, the organic solution is dried and concentrated and the residue is recrystallized to give 2-dimethylamino-N-methyl-2-(2-pyridyl)thioacetamide.

Workup

  1. additionA mixture of 7.5 g
  2. temperaturecooled
  3. extractionThe solution is extracted with chloroform
  4. customthe organic solution is dried
  5. concentrationconcentrated
  6. customthe residue is recrystallized

Sources & evidence

ORD record
ord-5b2b087a3df842a79e95f161676b553a
Source dataset
uspto-grants-1976_04
Patent number
US03948892

Reaction notes

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