Morpholine → HCID 21548161, compound

HRID 1604901Notes

Reaction equation

HRID 1604901 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5](Cl)=[C:4]2[CH:9]=[N:10][C:11]([CH3:15])=[C:12]([O:13][CH3:14])[C:3]=12.[NH:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1>>[CH3:15][C:11]1[N:10]=[CH:9][C:4]2=[C:5]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)[N:6]=[N:7][C:2]([N:16]3[CH2:21][CH2:20][O:19][CH2:18][CH2:17]3)=[C:3]2[C:12]=1[O:13][CH3:14]

Participants

3

Reactant 2

HCID 8083MorpholineHCID 21548163HCID 21548163, compound

Product 1

HCID 21548161HCID 21548161, compound

Procedure

0.5 part by weight of 1,4-dichloro-7-methyl-8-methoxypyrido[3,4-d]pyridazine and 3.6 parts by weight of morpholine are heated together at 80°C for 1.5 hour and, then, the excess morpholine is distilled off. To the residue is added water, whereupon an oily precipitate is obtained. This oil is triturated with a small amount of methanol to obtain crystals of 7-methyl-8-methoxy-1,4-dimorpholinopyrido[3,4-d]pyridazine. Recrystallization from a mixture of methanol and water (1:3) yields crystals melting at 145°-146°C. Yield 0.5 part by weight.

Workup

  1. distillationthe excess morpholine is distilled off
  2. additionTo the residue is added water
  3. customwhereupon an oily precipitate is obtained
  4. customThis oil is triturated with a small amount of methanol

Sources & evidence

ORD record
ord-5b4219b4f01a430fb8eb9777be5045c2
Source dataset
uspto-grants-1976_04
Patent number
US03948908

Reaction notes

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