Morpholine → HCID 21548161, compound

Participants

Reaction Steps

0.5 part by weight of 1,4-dichloro-7-methyl-8-methoxypyrido[3,4-d]pyridazine and 3.6 parts by weight of morpholine are heated together at 80°C for 1.5 hour and, then, the excess morpholine is distilled off. To the residue is added water, whereupon an oily precipitate is obtained. This oil is triturated with a small amount of methanol to obtain crystals of 7-methyl-8-methoxy-1,4-dimorpholinopyrido[3,4-d]pyridazine. Recrystallization from a mixture of methanol and water (1:3) yields crystals melting at 145°-146°C. Yield 0.5 part by weight.

Provenance & Evidence