Morpholine → HCID 12246656, compound

HRID 1604902Notes

Reaction equation

HRID 1604902 reaction equation
Cl[C:2]1[N:7]=[N:6][C:5](Cl)=[C:4]2[C:9]([CH3:21])=[N:10][C:11]([C:13]3[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=3)=[CH:12][C:3]=12.[NH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>>[CH3:20][O:19][C:16]1[CH:17]=[CH:18][C:13]([C:11]2[N:10]=[C:9]([CH3:21])[C:4]3=[C:5]([N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)[N:6]=[N:7][C:2]([N:22]4[CH2:27][CH2:26][O:25][CH2:24][CH2:23]4)=[C:3]3[CH:12]=2)=[CH:14][CH:15]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 12246634HCID 12246634, compound

Product 1

HCID 12246656HCID 12246656, compound

Conditions

Temperature
130 °C

Procedure

1.0 part by weight of 1,4-dichloro-7-(p-methoxyphenyl)-5-methylpyrido[3,4-d]pyridazine is added to 10 parts by volume of morpholine, and the resulting mixture is heated at 130°C for 3 hours. The excess amount of morpholine is removed by evaporating under reduced pressure, and water is added to the residue. The crude crystals are collected by filtration and recrystallized from ethanol to obtain 7-(p-methoxyphenyl)-5-methyl-1,4-dimorpholinopyrido[3,4-d]pyridazine as gray prisms melting at 206° to 209°C.

Workup

  1. customThe excess amount of morpholine is removed
  2. customby evaporating under reduced pressure, and water
  3. additionis added to the residue
  4. filtrationThe crude crystals are collected by filtration
  5. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-63ef6d0718ed463c85b578946c337f17
Source dataset
uspto-grants-1976_04
Patent number
US03948908

Reaction notes

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