Morpholine → HCID 12246656, compound

Participants

Reaction Conditions

Reaction Steps

1.0 part by weight of 1,4-dichloro-7-(p-methoxyphenyl)-5-methylpyrido[3,4-d]pyridazine is added to 10 parts by volume of morpholine, and the resulting mixture is heated at 130°C for 3 hours. The excess amount of morpholine is removed by evaporating under reduced pressure, and water is added to the residue. The crude crystals are collected by filtration and recrystallized from ethanol to obtain 7-(p-methoxyphenyl)-5-methyl-1,4-dimorpholinopyrido[3,4-d]pyridazine as gray prisms melting at 206° to 209°C.

Provenance & Evidence