Hydrochloric Acid → HCID 21490209, compound

HRID 1604904Notes

Reaction equation

HRID 1604904 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[N:12]=[N:11][C:10]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[C:9]3[CH:19]=[N:20][C:21]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)=[CH:22][C:8]=23)[CH2:3][CH2:2]1.[ClH:29]>C(O)C>[ClH:29].[O:1]1[CH2:2][CH2:3][N:4]([C:7]2[N:12]=[N:11][C:10]([N:13]3[CH2:18][CH2:17][O:16][CH2:15][CH2:14]3)=[C:9]3[CH:19]=[N:20][C:21]([C:23]4[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=4)=[CH:22][C:8]=23)[CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 1004941,4-Dimorpholino-7-phenylpyrido(3,4-d)pyridazine

Product 1

HCID 21490209HCID 21490209, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

One part by weight of 1,4-dimorpholino-7-phenylpyrido[3,4-d]pyridazine is dissolved in 50 parts by volume of ethanol under warming. Ten parts by volume of a 10% hydrogen chloride ethanolic solution is added to the solution and the resulting mixture is cooled to precipitate 1,4-dimorpholino-7-phenylpyrido[3,4-d]pyridazine hydrochloride. The product (one part by weight) is collected by filtration and recrystallized from 50 parts by volume of ethanol to obtain highly purities 1,4-dimorpholino-7-phenylpyrido[3,4-d]pyridazine hydrochloride melting at 176 to 181°C as orange needles.

Workup

  1. temperatureunder warming
  2. temperaturethe resulting mixture is cooled
  3. customto precipitate 1,4-dimorpholino-7-phenylpyrido[3,4-d]pyridazine hydrochloride
  4. filtrationThe product (one part by weight) is collected by filtration
  5. customrecrystallized from 50 parts by volume of ethanol

Sources & evidence

ORD record
ord-5707042ae01540e1a9223aa6002ba51a
Source dataset
uspto-grants-1976_04
Patent number
US03948908

Reaction notes

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