Sec-Butylamine → HCID 21400873, compound

HRID 1604950Notes

Reaction equation

HRID 1604950 reaction equation
[CH3:1][C:2]1[N:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[C:4]([NH:12][CH:13]([CH3:15])[CH3:14])[N:3]=1.[CH:16]([NH2:20])([CH2:18][CH3:19])[CH3:17]>C(N(CC)CC)C>[CH3:1][C:2]1[N:3]=[C:4]([NH:12][CH:13]([CH3:15])[CH3:14])[C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH:20][CH:16]([CH2:18][CH3:19])[CH3:17])[N:7]=1

Participants

4

Reactant 2

HCID 24874Sec-ButylamineHCID 3697918HCID 3697918, compound

Product 1

HCID 21400873HCID 21400873, compoundYield 96.2%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

10 ml of triethylamine are added to 8.05 g (0.035 mol) of 2-methyl-4-chloro-5-nitro-6-isopropylamino-pyrimidine. While cooling with ice, 7.3 g (0.1 mol) of sec- butylamine are slowly added dropwise and the mixture is stirred for 16 hours at room temperature. The reaction solution is evaporated, the residue suspended in 500 ml of water and extracted 3 times with ether, to yield 9.0 g of 2-methyl-4-isopropylamino-6-sec.butylamino-5-nitro-pyrimidine (36.5 %) as an oil.

Workup

  1. additionare slowly added dropwise
  2. customThe reaction solution is evaporated
  3. extractionextracted 3 times with ether

Sources & evidence

ORD record
ord-adc1d38acc374e4ba3a73833799094a5
Source dataset
uspto-grants-1976_04
Patent number
US03948914

Reaction notes

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