Triethylamine → HCID 54290981, compound

HRID 1604954Notes

Reaction equation

HRID 1604954 reaction equation
[CH2:1]([NH:3][C:4]1[C:9]([N+:10]([O-:12])=[O:11])=[C:8](Cl)[N:7]=[C:6]([C:14]([F:17])([F:16])[F:15])[N:5]=1)[CH3:2].C(N(CC)CC)C.[NH2:25][CH:26]([CH2:28][CH3:29])[CH3:27]>C(O)C>[CH2:1]([NH:3][C:4]1[C:9]([N+:10]([O-:12])=[O:11])=[C:8]([NH:25][CH:26]([CH2:28][CH3:29])[CH3:27])[N:7]=[C:6]([C:14]([F:17])([F:16])[F:15])[N:5]=1)[CH3:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 24874Sec-ButylamineHCID 214008916-Chloro-N-ethyl-5-nitro-2-(trifluoromethyl)pyrimidin-4-amine

Product 1

HCID 54290981HCID 54290981, compoundYield 73.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5.4 g (0.02 mol) of 4-ethylamino-6-chloro-5-nitro-2-trifluoromethyl-pyrimidine are dissolved in 100 ml of abs. ethanol. The solution is treated with 2.3 g of triethylamine (0.023 mol) and 1.7 g (0.023 mol) of 2-amino-butane and the mixture is stirred overnight. After the mixture has been evaporated, the product is taken up in water and extracted with ether to yield 4.5 g of 4-ethylamino-5-nitro-6-(2-butylamino)-2-trifluoromethyl-pyrimidine; nD20 = 1.5209.

Workup

  1. customAfter the mixture has been evaporated
  2. extractionextracted with ether

Sources & evidence

ORD record
ord-1143177c08804b628b179d8b4b1375cb
Source dataset
uspto-grants-1976_04
Patent number
US03948914

Reaction notes

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