Triphenylphosphine → HCID 70617022, compound

HRID 1604969Notes

Reaction equation

HRID 1604969 reaction equation
C([C:3]1[CH:8]([C:9]([O:11][CH:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[N:7]2[C:25](=[O:36])[CH:26]([NH:27][C:28](=[O:35])[CH2:29][C:30]3[S:31][CH:32]=[CH:33][CH:34]=3)[C@H:6]2[S:5][CH:4]=1)=O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>Cl[Rh].C1(C)C=CC=CC=1>[CH:12]([O:11][C:9]([C:8]1[N:7]2[C:25](=[O:36])[CH:26]([NH:27][C:28](=[O:35])[CH2:29][C:30]3[S:31][CH:32]=[CH:33][CH:34]=3)[C@H:6]2[S:5][CH2:4][CH:3]=1)=[O:10])([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:19]1[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=1

Participants

5

Reactant 2

HCID 11776TriphenylphosphineHCID 88777142HCID 88777142, compound

Product 1

HCID 70617022HCID 70617022, compound

Reagents, catalysts & solvents 2

HCID 178479812HCID 178479812, compoundCatalystHCID 1140TolueneSolvent

Procedure

A mixture of the benzhydryl ester from Example 28 (2.5 g, 4.79 mmol), tris-(triphenylphosphine(chlororhodium (3.5 g, 4.79 mmol) and dry toluene (75 ml) was refluxed under nitrogen for 5.5. hours. The reaction mixture was cooled. the rhodium complex was removed by filtration and the filtrate was poured slowly into petroleum ether (250 ml) with stirring. The precipitated solid, which was a mixture of rhodium complex and product, was collected. The product was purified by chromatography on a silica gel column (250 g) using 99:0.5 chloroform:ethyl acetate as eluent. Fractions of 4.5 ml were collected; fractions 1-47 discarded, 48-66 contained bis-(triphenylphosphine)carbonylchlororhodium, and 67-198 contained the product. NMR data indicated the product after chromatography to be the Δ3 isomer instead of the Δ2 isomer. A decoupling experiment showed the 2-methylene group at 3.3 ppm. to be coupled with the 3-proton at 6.6 ppm.

Workup

  1. temperatureThe reaction mixture was cooled
  2. customthe rhodium complex was removed by filtration
  3. additionthe filtrate was poured slowly into petroleum ether (250 ml)
  4. additiona mixture of rhodium complex and product
  5. customwas collected
  6. customThe product was purified by chromatography on a silica gel column (250 g)
  7. customFractions of 4.5 ml were collected

Sources & evidence

ORD record
ord-ff5df22735e24e27ac62406274363931
Source dataset
uspto-grants-1976_04
Patent number
US03948905

Reaction notes

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