Chloroacetyl chloride → HCID 21403930, compound

HRID 1605045Notes

Reaction equation

HRID 1605045 reaction equation
[S:1]1[CH2:7][CH2:6][CH2:5][CH2:4][S:3][CH:2]1[CH2:8][NH:9][C:10]1[C:15]([CH2:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:18][CH3:19].C(=O)(O)[O-].[Na+].O1CCOCC1.[Cl:31][CH2:32][C:33](Cl)=[O:34]>CCOCC.O>[Cl:31][CH2:32][C:33]([N:9]([CH2:8][CH:2]1[S:3][CH2:4][CH2:5][CH2:6][CH2:7][S:1]1)[C:10]1[C:15]([CH2:16][CH3:17])=[CH:14][CH:13]=[CH:12][C:11]=1[CH2:18][CH3:19])=[O:34]

Participants

7

Reactant 4

HCID 6577Chloroacetyl chlorideHCID 312751,4-DioxaneHCID 516892Sodium BicarbonateHCID 21548993HCID 21548993, compound

Product 1

HCID 21403930HCID 21403930, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 3283Diethyl EtherSolvent

Procedure

N-(1,3-Dithiepan-2-ylmethyl)-2,6-diethylaniline (15 grams), sodium bicarbonate (10 grams), dioxane (30 ml) and water (5 ml) are charged into a glass reaction vessel equipped with a mechanical stirrer and thermometer. The mixture is cooled to a temperature of about 0°C and chloroacetyl chloride (7 grams) is added, with stirring, over a period of about 15 minutes. After the addition is completed stirring is continued for a period of about 1 hour. After this time ether (100 ml) is added to the mixture and the resulting solution is washed with water. The washed solution is then dried over anhydrous magnesium sulfate and stripped of solvents leaving a solid residue. The residue is recrystallized to yield the desired product N-α-chloroacetyl-N-(1,3-dithiepan-2-ylmethyl)-2,6 -diethylaniline.

Workup

  1. customequipped with a mechanical stirrer
  2. additionis added
  3. additionAfter the addition
  4. stirringis completed stirring
  5. waitis continued for a period of about 1 hour
  6. washthe resulting solution is washed with water
  7. dry with materialThe washed solution is then dried over anhydrous magnesium sulfate
  8. customleaving a solid residue
  9. customThe residue is recrystallized

Sources & evidence

ORD record
ord-20195ef56c5547009c5e4162d12a9f1e
Source dataset
uspto-grants-1976_04
Patent number
US03948950

Reaction notes

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