反应详情

To 40 g. 9-benzyl-1,2,3,4-tetrahydrocarbazole-4-carboxylic acid in one liter of liquid ammonia was added, with stirring and portionwise, 8.6 g. of sodium. Ammonium chloride was added portionwise until the blue color of the mixture was dissipated. The ammonia was evaporated, water was added and the mixture was extracted with ether. The aqueous solution was chilled and acidified with dilute hydrochloric acid and the resulting solid was collected by filtration and washed with water to give 23 g. of the title compound; m.p. 163°-165°C. (benzene-methyl alcohol).

1. customThe ammonia was evaporated
2. additionwater was added
3. extractionthe mixture was extracted with ether
4. temperatureThe aqueous solution was chilled
5. filtrationthe resulting solid was collected by filtration
6. washwashed with water
7. customto give 23 g