Ammonia → 1-(2-Aminoethyl)-1,4,5,6-tetrahydropyrimidine

HRID 1605155Notes

Reaction equation

HRID 1605155 reaction equation
[N:1]1([CH2:7][CH:8]=O)[CH2:6][CH2:5][CH2:4][N:3]=[CH:2]1.[NH3:10].[H][H]>[Ni].C(O)C>[NH2:10][CH2:8][CH2:7][N:1]1[CH2:6][CH2:5][CH2:4][N:3]=[CH:2]1

Participants

6

Reactant 3

HCID 222AmmoniaHCID 540906671,4,5,6-Tetrahydropyrimidine-1-acetaldehydeHCID 178418361HCID 178418361, compound

Product 1

HCID 215494801-(2-Aminoethyl)-1,4,5,6-tetrahydropyrimidine

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

A suspension of 0.20 g. of Raney nickel, 6.3 g. of 1,4,5,6-tetrahydropyrimidine-1-acetaldehyde and 1.7 g. of ammonia in 50 ml. of ethanol is shaken under 20 atmospheres of hydrogen at 40° C. until one equivalent is absorbed. The catalyst is filtered off and the solvent is removed in vacuo to give 1-(2-aminoethyl)-1,4,5,6-tetrahydropyrimidine.

Workup

  1. additionA suspension of 0.20 g
  2. customis absorbed
  3. filtrationThe catalyst is filtered off
  4. customthe solvent is removed in vacuo

Sources & evidence

ORD record
ord-c6b78d0a8b02459e8c87e45c1dac8a7d
Source dataset
uspto-grants-1976_04
Patent number
US03949076

Reaction notes

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