HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → 1-(2-Aminoethyl)-1,4,5,6-tetrahydropyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | 1,4,5,6-Tetrahydropyrimidine-1-acetaldehyde | HCID 54090667 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1-(2-Aminoethyl)-1,4,5,6-tetrahydropyrimidine | HCID 21549480 | — |
Reaction Steps
A suspension of 0.20 g. of Raney nickel, 6.3 g. of 1,4,5,6-tetrahydropyrimidine-1-acetaldehyde and 1.7 g. of ammonia in 50 ml. of ethanol is shaken under 20 atmospheres of hydrogen at 40° C. until one equivalent is absorbed. The catalyst is filtered off and the solvent is removed in vacuo to give 1-(2-aminoethyl)-1,4,5,6-tetrahydropyrimidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03949076 |
| Source dataset | uspto-grants-1976_04 |
| ORD ID | ord-c6b78d0a8b02459e8c87e45c1dac8a7d |
| Source note | uspto-grants-1976_04 |