Sodium Hydroxide → HCID 21546685, compound

HRID 1605218Notes

Reaction equation

HRID 1605218 reaction equation
Cl.[O:2]1[CH2:7][CH2:6][N:5]([N+:8]2[N-:9][O:10][C:11](=[NH:13])[CH:12]=2)[CH2:4][CH2:3]1.[OH-:14].[Na+]>O>[O:2]1[CH2:7][CH2:6][N:5]([N:8]([CH2:12][C:11]([NH2:13])=[O:10])[N:9]=[O:14])[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 9859122HCID 9859122, compound

Product 1

HCID 21546685HCID 21546685, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 4.1 g of 3-morpholino-sydnonimine hydrochloride dissolved in 10 ml of water is added with stirring 1.440 g of 40% aqueous sodium hydroxide. The reaction mixture is stirred for 1 hour. The aqueous solution is concentrated and cooled. Two crops of crystals are collected, combined and recrystallized from a 2 to 1 solution of chloroform and methanol. Two crops of the purified product, α-(N-morpholino-N-nitrosoamino)acetamide, m.p. 134° - 136° C., are collected.

Workup

  1. additionis added
  2. concentrationThe aqueous solution is concentrated
  3. temperaturecooled
  4. customTwo crops of crystals are collected
  5. customrecrystallized from a 2 to 1 solution of chloroform and methanol
  6. customTwo crops of the purified product, α-(N-morpholino-N-nitrosoamino)acetamide, m.p. 134° - 136° C., are collected

Sources & evidence

ORD record
ord-6b4bba01af344bf5b943716de2184e8f
Source dataset
uspto-grants-1976_04
Patent number
US03950332

Reaction notes

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