2-Methoxybenzaldehyde → HCID 70631740, compound

HRID 1605226Notes

Reaction equation

HRID 1605226 reaction equation
[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=O.[CH2:11]([O:13][C:14](=[O:19])[CH2:15][C:16](=[NH:18])[NH2:17])[CH3:12]>C(O)C>[CH2:11]([O:13][C:14]([C:15]1[CH:5]([C:4]2[CH:7]=[CH:8][CH:9]=[CH:10][C:3]=2[O:2][CH3:1])[C:15]([C:14]([O:13][CH2:11][CH3:12])=[O:19])=[C:16]([NH2:17])[NH:18][C:16]=1[NH2:17])=[O:19])[CH3:12]

Participants

4

Reactant 2

HCID 86582-MethoxybenzaldehydeHCID 4599837Carbamimidoyl-acetic acid ethyl ester

Product 1

HCID 70631740HCID 70631740, compoundYield 72%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Upon boiling a solution of 6.8 g 2-methoxybenzaldehyde and 13.0 g amidinoacetic acid ethyl ester in 150 ml ethanol for 2 hours, 2,6-diamino-4-(2-methoxyphenyl)-1,4-dihydropyridine- 3,5-dicarboxylic acid diethyl ester of m.p. 147°C (ethanol) is obtained.

Workup

  1. customfor 2 hours

Sources & evidence

ORD record
ord-65267e4383d74870acc2c231ecabf4b2
Source dataset
uspto-grants-1976_04
Patent number
US03950336

Reaction notes

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