1-Methylpiperazine → HCID 22756830, compound

HRID 1605257Notes

Reaction equation

HRID 1605257 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.Cl[C:9]1[N:10]=[CH:11][C:12]2[C:18](=[O:19])[C:17]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:16][N:15]([CH3:25])[C:13]=2[N:14]=1>C(O)C>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([C:9]2[N:10]=[CH:11][C:12]3[C:18](=[O:19])[C:17]([C:20]([O:22][CH2:23][CH3:24])=[O:21])=[CH:16][N:15]([CH3:25])[C:13]=3[N:14]=2)[CH2:4][CH2:3]1

Participants

4

Reactant 2

HCID 531671-MethylpiperazineHCID 22756847HCID 22756847, compound

Product 1

HCID 22756830HCID 22756830, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

1.5 g of N-methylpiperazine are added to a stirred suspension of 2 g of 2-chloro-5-oxo-6-carbethoxy-8-methyl-5,8-dihydro-pyrido(2,3-d)pyrimidine in 20 cm3 of absolute ethanol. The reaction takes place with evolution of heat. After standing for 2 hours at room temperature, the solvent is evaporated in vacuo, the residue is taken up in water and the precipitate is filtered off, washed, dried in vacuo and recrystallised from benzene: 1.4 g (58%) of 2-(4'-methyl-piperazino)-5-oxo-6-carbethoxy-8-methyl-5,8-dihydro-pyrido(2,3-d)-pyrimidine are obtained.

Workup

  1. temperatureof heat
  2. customthe solvent is evaporated in vacuo
  3. filtrationthe precipitate is filtered off
  4. washwashed
  5. customdried in vacuo
  6. customrecrystallised from benzene

Sources & evidence

ORD record
ord-cad74a84de554274a39fe92fdc4a7f8c
Source dataset
uspto-grants-1976_04
Patent number
US03950338

Reaction notes

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