Acetic Anhydride → HCID 10976496, compound

HRID 1605266Notes

Reaction equation

HRID 1605266 reaction equation
Cl.[NH:2]1[C:12]2[C:13]3[C:4]([CH2:5][NH:6][CH2:7][C:8]=3[CH:9]=[CH:10][CH:11]=2)=[CH:3]1.[C:14](OC(=O)C)(=[O:16])[CH3:15]>N1C=CC=CC=1>[C:14]([N:6]1[CH2:5][C:4]2=[CH:3][NH:2][C:12]3[C:13]2=[C:8]([CH:9]=[CH:10][CH:11]=3)[CH2:7]1)(=[O:16])[CH3:15]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 3041096Pyrrolo(4,3,2-de)isoquinoline, 1,3,4,5-tetrahydro-, monohydrochloride

Product 1

HCID 10976496HCID 10976496, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 1,3,4,5-tetrahydropyrrolo[4,3,2-de]isoquinoline hydrochoride (9.8 g), described in Example 5, in 30 ml of pyridine and 10 ml of acetic anhydride is heated at 50°C for 2 hr. The excess anhydride is destroyed by the addition of water. The mixture is poured into cold 5% HCl. The resulting precipitate is collected and recrstallized from ethanol to give 4-acetyl-1,3,4,5 -tetrahydropyrrolo[4,3,2-de]isoquinoline, mp 205°-206°C.

Workup

  1. customThe excess anhydride is destroyed by the addition of water
  2. additionThe mixture is poured into cold 5% HCl
  3. customThe resulting precipitate is collected

Sources & evidence

ORD record
ord-bf985862471e4cda983ba25aa80e1984
Source dataset
uspto-grants-1976_04
Patent number
US03950343

Reaction notes

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