Acetic Anhydride → HCID 10976496, compound

Participants

Reaction Steps

A mixture of 1,3,4,5-tetrahydropyrrolo[4,3,2-de]isoquinoline hydrochoride (9.8 g), described in Example 5, in 30 ml of pyridine and 10 ml of acetic anhydride is heated at 50°C for 2 hr. The excess anhydride is destroyed by the addition of water. The mixture is poured into cold 5% HCl. The resulting precipitate is collected and recrstallized from ethanol to give 4-acetyl-1,3,4,5 -tetrahydropyrrolo[4,3,2-de]isoquinoline, mp 205°-206°C.

Provenance & Evidence